This design layout is good if you want to have a lot of text in the work.
With the thumbnails positioned on either the left or right, it makes the main image smaller, which then allows more room for the text.
Text on the right with main image on the left. Single row thumbnails above main image.
Text - Single column on the right.
Note: Adding thumbnails on the sides, resizes the main image accordingly (See example 3 & 3a)